Table 2. Association of the immunohistochemistry data with the hypoxic status of the tumor.
| Rule | if HIF-1α is |
andif PDK1 is |
andif PHD3 is |
then | Occurrence | Coverage | Confidence | Lift | Leverage | Conviction | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| If | then | ||||||||||
| R1 | high | = = >Hypoxia = high | 11 | 8 | 1.00 | 0.73 | 2.27 | 0.18 | 1.87 | ||
| R2 | high | = = >Hypoxia = high | 9 | 7 | 0.88 | 0.78 | 2.43 | 0.16 | 2.04 | ||
| R3 | low | = = >Hypoxia = high | 10 | 8 | 1.00 | 0.8 | 2.5 | 0.19 | 2.27 | ||
| R4 | high | low | = = >Hypoxia = high | 8 | 8 | 1.00 | 1 | 3.13 | 0.22 | 5.44 | |
| R5 | high | high | = = >Hypoxia = high | 8 | 7 | 0.88 | 0.88 | 2.73 | 0.18 | 2.72 | |
| R6 | high | low | = = >Hypoxia = high | 7 | 7 | 0.88 | 1 | 3.13 | 0.19 | 4.76 | |
| R7 | high | high | low | = = >Hypoxia = high | 7 | 7 | 0.88 | 1 | 3.13 | 0.19 | 4.76 |
| R8 | low | = = >Hypoxia = low | 14 | 14 | 0.82 | 1 | 1.47 | 0.18 | 4.48 | ||
| R9 | low | = = >Hypoxia = low | 16 | 15 | 0.88 | 0.94 | 1.38 | 0.16 | 2.56 | ||
| R10 | high | = = >Hypoxia = low | 15 | 15 | 0.88 | 1 | 1.47 | 0.19 | 4.8 | ||
| R11 | low | low | = = >Hypoxia = low | 13 | 13 | 0.76 | 1 | 1.47 | 0.17 | 4.16 | |
| R12 | low | high | = = >Hypoxia = low | 12 | 12 | 0.71 | 1 | 1.47 | 0.15 | 3.84 | |
| R13 | low | high | = = >Hypoxia = low | 13 | 13 | 0.76 | 1 | 1.47 | 0.17 | 4.16 | |
| R14 | low | low | high | = = >Hypoxia = low | 11 | 11 | 0.65 | 1 | 1.47 | 0.14 | 3.52 |
Rules were generated by the APRIORI algorithm to associate the immunohistochemistry results for HIF-1α, PDK1 and PHD3 with the hypoxic status of the tumor.