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. 2017 Jun 22;1(6):538–549. doi: 10.1002/hep4.1060

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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RNA dynamics and S282T emergence in SOF‐ or LDV/SOF‐treated patients. (A) Emergent S282T substitution in patient 1 (GT2b infection) and patient 2 (GT1b infection), who were treated with SOF monotherapy. (B) Emergent S282T substitution in patient 3 (GT1a infection) treated with LDV/SOF. (C) Emergent S282T substitution in three patients with GT1a infection (patients 4, 5, and 6) retreated with LDV/SOF. (D) Emergent S282T substitution in patients infected with non‐GT1 HCV (patients 7, 8, 9, and 10) who were treated with LDV/SOF.