Table 1.
CLINICAL AND SEROLOGICAL CHARACTERISTICS OF THE SUBJECTS
| Variables | Biopsy‐Proven NAFLD Patients | Health Check‐Up Subjects | ||||
|---|---|---|---|---|---|---|
| NAFL | NASH | P Value* | Fatty Liver (–) | Fatty Liver (+) | P Value* | |
| Number | 200 | 310 | 831 | 1291 | ||
| Age (y) | 50.7 ± 10.3 | 52.8 ± 14.2 | <0.005 | 54.1 ± 8.7 | 54.6 ± 7.0 | <0.05 |
| Sex (M/F) | 69/131 | 141/169 | <0.0001 | 473/358 | 1022/269 | <0.0001 |
| BMI (kg/m2) | 26.0 ± 3.9 | 28.1 ± 5.1 | <0.0005 | 21.9 ± 2.7 | 26.0 ± 3.6 | <0.0001 |
| AST (U/L) | 42.0 ± 26.3 | 64.2 ± 44.1 | <0.0001 | 24.3 ± 14.2 | 31.1 ± 16.8 | <0.0001 |
| ALT (U/L) | 75.4 ± 49.8 | 98.0 ± 73.8 | <0.01 | 23.4 ± 23.0 | 41.1 ± 24.0 | <0.0001 |
| GGT (U/L) | 111.0 ± 143.1 | 88.5 ± 79.7 | N.S. | 50.5 ± 94.4 | 74.5 ± 94.2 | <0.0001 |
| ALP (U/L) | 238.3 ± 85.4 | 274.9 ± 125.8 | <0.05 | 200.9 ± 74.8 | 210.9 ± 58.0 | <0.0001 |
| CHE (U/L) | 368.4 ± 75.3 | 363.4 ± 89.1 | N.S. | 316.1 ± 71.7 | 376.9 ± 67.2 | <0.0001 |
| T‐Chol (mg/dL) | 193.2 ± 36.7 | 206.1 ± 36.0 | N.S. | 194.9 ± 30.8 | 208.7 ± 35.3 | <0.0001 |
| TG (mg/dL) | 136.2 ± 93.6 | 143.2 ± 64.4 | N.S. | 92.3 ± 80.3 | 155.4 ± 106.9 | <0.0001 |
| HDL‐C (mg/dL) | 49.2 ± 12.0 | 49.2 ± 15.2 | N.S. | 64.7 ± 14.3 | 54.3 ± 11.7 | <0.0001 |
| FBS (mg/dL) | 98.6 ± 15.1 | 106.1 ± 25.0 | N.S. | 108.3 ± 28.1 | 120.2 ± 32.1 | <0.0001 |
| IRI (mU/mL) | 10.1 ± 5.6 | 14.7 ± 9.1 | <0.05 | N.D. | N.D. | |
| Albumin (g/dL) | 4.57 ± 0.38 | 4.42 ± 0.45 | <0.05 | 4.24 ± 0.22 | 4.39 ± 0.22 | <0.0001 |
| Ferritin (ng/mL) | 179.2 ± 127.3 | 287.0 ± 285.7 | <0.005 | N.D. | N.D. | |
| Hyaluronic acid (ng/mL) | 37.4 ± 37.4 | 106.5 ± 206.6 | <0.05 | N.D. | N.D. | |
| Platelet count (× 104/μL) | 23.8 ± 5.6 | 22.1 ± 6.9 | N.S. | 21.7 ± 5.4 | 22.0 ± 5.1 | 0.07 |
| FIB4 index | 1.00 ± 0.53 | 1.97 ± 1.47 | <0.0001 | 1.39 ± 0.65 | 1.33 ± 0.70 | <0.005 |
| NFS | –2.40 ± 1.32 | –1.56 ± 1.56 | <0.0001 | –1.71 ± 1.11 | –1.53 ± 1.13 | <0.0005 |
| Mac‐2bp (μg/mL) | 1.46 ± 0.77 | 2.74 ± 1.52 | <0.0001 | 1.11 ± 0.69 | 1.81 ± 1.09 | <0.0001 |
| WFA+‐M2BP (COI) | N.D. | N.D. | 0.51 ± 0.36 | 0.60 ± 0.31 | <0.0001 | |
Data are presented as the mean ± SD. *P values correspond to the comparison between NAFL and NASH groups. Wilcoxon test for continuous factors and Pearson's chi‐square test for categorical factors were used.
Abbreviations: CHE, choline esterase; GGT, gamma glutamyltranspeptidase; HDL‐C, high‐density lipoprotein cholesterol; N.D., not determined; N.S., not significant; T‐Chol, total cholesterol; TG, triglyceride.