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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Pharmacogenet Genomics. 2017 Dec;27(12):454–463. doi: 10.1097/FPC.0000000000000312

Figure 3. Effect of Enhancer Variants In Vivo.

Figure 3

The luciferase activity in mouse liver homogenates was measured 24 hr after plasmid injection. Enhancer activity is expressed as the ratio of firefly to Renilla luciferase activity normalized to the empty vector (pGL4.23) activity. An enhancer for ApoE was used as the positive control[21]. Data is expressed as the mean ± SEM for 4–11 mice. Differences between reference and variant enhancer elements were tested by an unpaired Student’s t-test (one variant) or an ANOVA followed by a Bonferroni’s multiple comparison t-test (for two or more variants); * P < 0.05, ** P < 0.001, *** P < 0.0001.