Table 4.
A comparison of our study with various heparin-free saline flush protocols
| Author/reference | Design | Population | Year | BFR (ml/min) | Average UF (L/session or L/h) (mean ± SD) | Saline flush regimen | Clotting of the EC (%) |
|---|---|---|---|---|---|---|---|
| This study (n = 1200) | Prospective | Inpatient, ESRD and AKI | 2014 | 350 | 1.87 ± 1.12 L/session | None | 5 |
| Sahota25 (n = 400) | Retrospective | Inpatient, ESRD and AKI | 2013 | >350 | 1 ± 0.817 L/session in treatments that clotted versus 2 ± 1.366 L/session in those that did not | 100 ml q15 min | 1 |
| Stamatiadis26 (n = 1224) | Retrospective | Inpatient, ESRD and AKI | 2004 | <250 | 0.891 ± 0.971 L/session | 50 ml q60 min | 5 |
| Schwab5 (n = 262) | Prospective | Inpatient, mostly ICU, strictly AKI | 1987 | 300 | 1.36 ± 0.003 L/h | 50−100 ml q15 min | 2a |
| Sanders6 (n = 158) | Retrospective | Inpatient, in kidney transplant recipients (perioperative and postoperative), ESRD and AKI | 1985 | 300 | Not provided | 100 ml q30 min | 5 complete 6 partial |
| Casati7 (n = 111) | Prospective | Inpatient, mostly post-transplant AKI, but some ESRD | 1983 | 300 | Not provided | 250−300 ml q15 min | 10 |
AKI, acute kidney injury; EC, extracorporeal circuit; ESRD, end-stage renal disease; ICU, intensive care unit.
a
Heparin was administered when early clotting of the EC was detected.