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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Circ Cardiovasc Imaging. 2017 Aug;10(8):e006427. doi: 10.1161/CIRCIMAGING.117.006427

Figure 2.

Figure 2

Coronary autoregulation and determinants of coronary flow reserve (CFR). Over the autoregulation range (the plateau of the autoregulation curve) coronary flow remains relatively constant despite changes in coronary perfusion pressure. CFR is determined by maximum hyperemic blood flow (solid red line) divided by baseline flow (solid green line). Increasing metabolic demand and reduced oxygen/nutrient delivery result in compensatory rise in baseline coronary flow (dashed green line). Increased baseline flow leads to a reduced CFR presuming stable or reduced hyperemic flow. Reduction in hyperemic coronary flow (dashed red line) can be induced by reduced diastolic filling time or coronary microvascular disease, and will also result in a decreased CFR.