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Relationship between myocardial blood flow and tracer uptake for common SPECT and PET radiotracers demonstrates a roll-off phenomenon at high flow rates, as uptake of some radiotracers becomes diffusion limited at higher flows. This results in reduced accuracy in the quantification of hyperemic coronary flow and CFR. Adapted from Salerno M. et al Circ Cardiovasc Imaging. 2009 Sep;2(5):412–24.2
