Annualized cardiac mortality among patients with diabetes mellitus (DM) or CAD. Adjusted cardiac mortality among patients with CAD (i.e., history of coronary revascularization or myocardial infarction) without DM (orange), DM patients without CAD who have impaired coronary flow reserve (CFR; red), DM patients without CAD who have preserved CFR (blue), and patients without DM or CAD with normal scans (no scar, ischemia, or left ventricular dysfunction; green) presented as survival curves (A) and annualized cardiac mortality rates (B). Data for patients with CAD and DM are also presented for comparison (purple). EF, ejection fraction; NI MPI, normal myocardial perfusion imaging; and CD, cardiac death. Adapted from Murthy VL, Circulation. 2012;126:1858–68.93