Skip to main content
. Author manuscript; available in PMC: 2018 Sep 26.
Published in final edited form as: J Am Coll Cardiol. 2017 Sep 26;70(13):1601–1615. doi: 10.1016/j.jacc.2017.07.789

Central Illustration. Effect of TNC on Pressure Overload-induced Cardiac Remodeling.

Central Illustration

We investigated the effect of tenascin-C (TNC) deficiency on pressure overload-induced cardiac remodeling. TNC deficiency exacerbated cardiac hypertrophy and maladaptive remodeling compared to controls, by increasing the infiltration of proinflammatory monocyte subsets into the myocardium. This suggests that TNC controls excessive remodeling of the myocardium in the pressure-overloaded heart. Reciprocal bone marrow transplantation studies revealed that the expression of TNC in the bone marrow, but not myocardium, accounts for TNC’s protective effect. LV = left ventricle; EF = ejection fraction.