Table 1.

Echo Parameters and Heart Mass Ratio

	Wild-type			TNCKO
	BL	1 Month	2 Months	BL	1 Month	2 Months
Number	16	16	8	16	16	8
Heart rate, beats/min	434 ± 34	448 ± 43	440 ± 31	436 ± 38	459 ± 34	449 ± 41
EF, %	67.2 ± 0.7	58.9 ± 2.6	51.3 ± 2.2	66.5 ± 0.6	48.9 ± 7.8*	39.8 ± 10.6*
FS, %	36.5 ± 0.5	30.6 ± 1.7	25.7 ± 1.3	35.9 ± 0.4	24.7 ± 4.6*	19.5 ± 5.7*
LVIDd, mm	3.42 ± 0.06	3.6 ± 0.18	3.65 ± 0.15	3.41 ± 0.04	4.31 ± 0.42*	4.53 ± 0.59*
LVIDs, mm	2.17 ± 0.05	2.51 ± 0.14	2.72 ± 0.15	2.18 ± 0.03	3.26 ± 0.48*	3.68 ± 0.76*
PWTd, mm	0.65 ± 0.06	0.76 ± 0.07	0.77 ± 0.1	0.67 ± 0.1	0.89 ± 0.13*	0.93 ± 0.11*
PWTs, mm	0.93 ± 0.09	1.09 ± 0.08	1.06 ± 0.12	0.97 ± 0.09	1.21 ± 0.14*	1.22 ± 0.09*
HW-BW, mg/g	3.99 ± 0.14	5.1 ± 0.09	5.5 ± 0.5	4.01 ± 0.15	6.95 ± 1.03*	8.1 ± 1.36*

Values are mean percent changes over baseline ± SD.

^*Significant change between tenascin-C knockout (TNCKO) and wild-type mice.

BL = baseline; BW = body weight; EF = ejection fraction; FS = fractional shortening; HW = heart weight; LVIDd = left ventricular internal diameter diastolic; LVIDs = left ventricular internal diameter systolic; PWTd = posterior wall thickness diastolic; PWTs = posterior wall thickness systolic.