Table 3.

AT II Effect on Echocardiographic Assessments and Heart Mass Ratios

	Wild-type		TNCKO
	Saline Vehicle	AT II	Saline Vehicle	AT II
Number	5	9	5	9
Heart rate, beats/min	440 ± 28	426 ± 36	435 ± 18	449 ± 55
EF, %	66.6 ± 1.9	52 ± 2.5†	67.8 ± 1.6	42.8 ± 7.3*†
FS, %	36.1 ± 1.5	26.3 ± 1.6†	37.1 ± 1	20.9 ± 4*†
LVIDd, mm	3.57 ± 0.12	3.96 ± 0.23†	3.5 ± 0.28	4.08 ± 0.33*†
LVIDs, mm	2.28 ± 0.04	2.92 ± 0.16†	2.2 ± 0.18	3.23 ± 0.38*†
PWTd, mm	0.6 ± 0.07	0.77 ± 0.03†	0.64 ± 0.03	0.85 ± 0.08*†
PWTs, mm	0.92 ± 0.07	1.05 ± 0.04†	0.88 ± 0.07	1.15 ± 0.09*†
HW-BW, mg/g	4.06 ± 0.24	4.78 ± 0.4†	4.02 ± 0.21	5.26 ± 0.46*†

Values are mean ± SD.

^*Significant difference between TNCKO and wild-type mice.

^†Significant difference between angiotensin (AT) II treatment and saline control group.

Other abbreviations as in Table 1.