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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: J Med Chem. 2016 Mar 29;59(7):3112–3128. doi: 10.1021/acs.jmedchem.5b01894

Figure 5.

Figure 5

Postulated rationale for linker-dependent preferences at the different melanocortin homodimer subtypes. The different linker systems had varying effects on enhancing binding or functional responses depending on which receptor subtype was expressed. Since the linkers connect the same pharmacophore, it appears the difference are due to the linkers' physicochemical properties such as linker length. These differences suggest that there are differences between the various subtypes of melanocortin receptor dimers such as the distance between tandem binding sites (see text). The figure demonstrates how different distances between tandem binding sites would show preference for the different length linker systems.