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. Author manuscript; available in PMC: 2018 Jun 21.
Published in final edited form as: ACS Chem Neurosci. 2017 Feb 16;8(6):1262–1278. doi: 10.1021/acschemneuro.6b00399

Table 1.

Sequence information of compounds used in the serum stability assays and their half-lives. Half-lives were calculated from two technical replicates of the in vitro serum stability assays (see Figure 1).

Analog Sequence Half-Life (h)
NDP-MSH Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 5.1
α-MSH Ac-Ser-Try-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 0.9
CJL-1-14 Ac-His-DPhe-Arg-Trp-NH2 16.8
CJL-1-87 Ac-His-DPhe-Arg-Trp-(PEDG20)-His-DPhe-Arg-Trp-NH2 6.0
CJL-5-35-4 Ac-His-DPhe-Arg-Trp-(PEDG20)-NH2 12.5
CJL-1-116 (PEDG20)-His-DPhe-Arg-Trp-NH2 10.6
CJL-1-31 Ac-His-DPhe-Arg-Trp-(Pro-Gly)6-His-DPhe-Arg-Trp-NH2 0.1
CJL-5-35-1 Ac-His-DPhe-Arg-Trp-(Pro-Gly)6-NH2 0.1
CJL-1-41 (Pro-Gly)6-His-DPhe-Arg-Trp-NH2 0.1