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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: Cell Signal. 2015 Nov 28;28(7):764–778. doi: 10.1016/j.cellsig.2015.11.014

Figure 1.

Figure 1

A) Experimental setup for the triple SILAC labeling experiments in MA10 cells comparing single PDE4 (Rolipram, Rol) or PDE8 (PF-04957325, PF) inhibitor treatment with PDE4 and 8 inhibitor combination treatment for 1 h and the setup of the time series experiment with PDE4 and 8 inhibitor treatment for 0, 1, 15, 60 and 180 minutes. B) Phosphoproteomics workflow according to which MA10 cell samples were processed and analyzed.