Table 2.

Biological processes highly regulated and corresponding genes that were found to be phospho-regulated on biologically characterized sites following MA10 cell treatment with PDE4 and 8 inhibitors. Arrows symbolize increased phosphorylation (↑) or decreased phosphorylation (↓) of a site.

Process	Gene	Site	Reg.	Cluster^a)	Function^b)	Ref.
Cell Cycle	Arhgef2	S885	↑	2	interaction, inhibition	[28]
	Clasp	S1004	↓	1	localization, inhibition	[30]
	Clasp	S1005	↓	1	localization, inhibition	[30]
	Flna	S2152	↑	2	interaction	[42]
	Kif20a	T855	↓	NA	localization, inhibition	[31]
	Ldlrap1	S14	↓	5	inhibition	[36]
	Mybl2	T519	↓	NA	inhibition	[40]
	Npm1	T232	↓	6	localization, inhibition	[37]
	Npm1	T235	↓	6	localization, inhibition	[37]
	Ttk	T277	↓	NA	localization, inhibition	[34, 35]
	Ttk	T820	↓	6	localization, inhibition	[34, 35]
	Vcip135	S746	↓	1	interaction, inhibition	[38]
MAPK Signaling	Araf	S255	↓	NA	inhibition	[47]
	Cdc25b	S351	↑	3	activation	[85]
	Egfr	T695	↑	2	endocytosis, inhibition	[86]
	Gab1	S552	↑	2	activation	[53]
	Grb14	S368	↑	NA	inhibition	[56, 57]
	Grb14	S370	↑	3	inhibition	[56, 57]
	Ksr1	S320	↓	5	activation	[51, 52]
	Ksr1	T270	↓	NA	activation	[51, 52]
	Map3k2	S153	↑	2	interaction	[87]
	Map3k2	S331	↑	2	interaction	[87]
	Map3k7	S412	↑	2	interaction	[88]
	Mapk1	T183	↑	3	activation
	Mapk1	Y185	↑	2	activation
	Mapk3	Y205	↑	2	activation
	Mapk14	T180	↑	4	activation
	Mapk14	Y182	↑	NA	activation
	Raf1	S43	↑	NA	interaction	[48]
	Rps6kb1	S447	↓	5	inhibition	[54, 89]
	Rps6kb1	S452	↓	1	inhibition	[54, 89]
Regulation Transcription/Metbolism	Amotl2	S752	↑	NA	activation	[90]
	Arhgap35	S1150	↑	NA	inhibition	[91]
	Crtc3	S62	↓	1	activation	[64]
		S329	↓	1	activation
		S370	↓	1	activation
	Ctnnb1	S552	↑	NA	activation	[70, 71]
	Esr1	S298	↓	NA	activation	[92]
	Itpr1	S1588	↑	NA	activation	[65]
	Lrrfip2	S111	↑	2	interaction	[73]
	Mlxipl	S196	↑	2	inhibition	[66]
	Mlxipl	S626	↑	2	inhibition	[66]
	Ptrf	S169	↑	NA	NA	[93]
		S302	↑	2	NA
		T304	↓	6	lipolysis, inhibition
	Sik3	S551	↑	2	activation	[63]
	Sik3	S674	↑	NA	activation	[63]
	Smad2	T8	↓	1	inhibition	[94]
	Yap1	S46	↑	1	inhibition	[68]
	Yap1	S352	↓	na	inhibition	[69]

^a)

Affiliation of a site to a temporal cluster (see Figure 3A).

^b)

Functional role of the phosphorylation event in the context of the biological process discussed.