Table 3.
Menin Interacting Proteins
| Protein | Function | Reference |
|---|---|---|
| NUCLEAR | ||
| Chromatin modification factors | ||
| DAXX | Transcriptional regulation | (Feng, et al. 2017) |
| HDACs, mSIN3A | Transcriptional regulation | (Kim, et al. 2003) |
| LEDGF | Transcriptional regulation | (Yokoyama and Cleary 2008) |
| MLL-complex (H3K4me3) (KMT2A/MLL1 or KMT2B/MLL2; ASH2L, hDPY30, HCF-2, RBBP5, RPB2/RNA-Pol-II, WDR5) | Transcriptional regulation | (Hughes et al. 2004; Yokoyama et al. 2005) |
| PRMT5 | Transcriptional regulation | (Gurung, et al. 2013a) |
| SuV39H1 (H3K9me3) | Transcriptional regulation | (Yang, et al. 2013) |
| Transcription factors | ||
| DNMT1 (Hedgehog pathway) | Transcriptional regulation | (Cheng, et al. 2016) |
| FBP1 | Transcriptional regulation | (Zaman, et al. 2014) |
| FOXA2 | Transcriptional regulation | (Bonnavion, et al. 2017) |
| HLXB9/MNX1 | Transcriptional regulation | (Shi, et al. 2013) |
| JUND | Transcriptional regulation | (Agarwal, et al. 1999; Gobl, et al. 1999) |
| c-MYB | Transcriptional regulation | (Jin, et al. 2010) |
| c-MYC | Transcriptional regulation | (Bres, et al. 2009) |
| NFκB - p50, p52, p65 | Transcriptional regulation | (Heppner, et al. 2001) |
| Nuclear receptors (AR, ERα, LXRα, PPARα, PPARϒ, RXR, VDR) | Transcriptional regulation | (Cheng, et al. 2015; Cheng, et al. 2011; Dreijerink, et al. 2006; Dreijerink, et al. 2009; Malik et al. 2015) |
| PEM | Transcriptional regulation | (Lemmens, et al. 2001) |
| RUNX2 (BMP2 signaling) | Transcriptional regulation | (Sowa, et al. 2004) |
| SMADs (TGFβ signaling) (SMAD1, SMAD3, SMAD5) | Transcriptional regulation | (Sowa et al. 2004) |
| SIRT1 | Transcriptional regulation | (Gang, et al. 2013) |
| SON | Transcriptional regulation | (Kim, et al. 2016) |
| TCF3, TCF4, β-Catenin (Wnt signaling) | Transcriptional regulation | (Cao et al. 2009) |
| Transcription initiation or elongation factors | ||
| RNA-Pol-II isoforms (pSer5 and pSer2) | Transcriptional regulation | (Francis et al. 2011) |
| SKIP (HIV-1 Tat:P-TEFb transcription) | Transcriptional regulation | (Bres et al. 2009) |
| Factors not associated with transcription | ||
| ASK | DNA replication and repair | (Schnepp, et al. 2004) |
| CHES1 | DNA replication and repair | (Busygina, et al. 2006) |
| FANCD2 | DNA replication and repair | (Jin, et al. 2003) |
| RPA2 | DNA replication and repair | (Sukhodolets, et al. 2003) |
| ARS2 | MicroRNA biogenesis | (Gurung, et al. 2014) |
| CHIP | Protein degradation | (Yaguchi, et al. 2004) |
| CYTOPLASMIC | ||
| AKT1 | Signaling | (Wang, et al. 2011) |
| FOXO1 | Signaling | (Wuescher, et al. 2011) |
| NM23β | Signaling | (Yaguchi, et al. 2002) |
| GFAP | Cell division/Adhesion/Motility | (Lopez-Egido, et al. 2002) |
| IQGAP1 | Cell division/Adhesion/Motility | (Yan, et al. 2009) |
| NMMHC-IIA | Cell division/Adhesion/Motility | (Obungu, et al. 2003) |
| VIMENTIN | Cell division/Adhesion/Motility | (Lopez-Egido et al. 2002) |