Table 4.
Prevalence of MEN1-associated tumors in Men1+/− mouse models compared to human MEN1
| Human (age 40) |
Mouse models (age >12 months) | ||||
|---|---|---|---|---|---|
| Crabtree, 2001 |
Bertolino, 2003 |
Loffler, 2007 |
Harding 2009 |
||
| Parathyroid | 90% | 24% | 47% | 9% | 85% |
| Pancreas | |||||
| Gastrinoma | 40% | -- | 15% | -- | -- |
| Insulinoma | 10% | 83% | 88% | 82% | 60% |
| Pituitary | |||||
| Prolactinoma | 20% | 26% | 12% | 10% | -- |
| Prolactin + GH secreting | 5% | -- | -- | -- | 32% |
| GH secreting | 5% | -- | 7% | -- | -- |
| ACTH secreting | 2% | -- | -- | -- | 3% |
| Adrenal | |||||
| Cortex NF | 25% | 20% | 35% | 10% | 10% |
| Pheochromocytoma | -- | 7% | -- | -- | 1% |
| Gonads | |||||
| Testis | -- | 22% | 88% | 47% | 60% |
| (Leydig cell in male) | |||||
| Ovary | -- | 31% | 8% | -- | 40% |
| (Sex-cord stromal in female) | |||||
NF = Non-functioning, GH = growth hormone, ACTH = adrenocorticotropic hormone