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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Semin Immunol. 2017 Oct;33:37–43. doi: 10.1016/j.smim.2017.08.006

Fig. 1. Host defense mechanisms enhanced by LTB4/BLT1 axis during microbial infection.

Fig. 1

Upper panel. Upon infection, microbial recognition triggers 5-LO activation to generate LTB4 in phagocytes. Lower panel. LTB4 amplifies macrophage and neutrophil effector function by enhancing the actions of different PRRs and FcR.