Table 3.
Change in VRAM performance measures for tertiles of tooth Mn levels
| Prenatal Mnc | All subjects (n=136, obs=1048)a | Girls (n=79, obs=606)b | Boys (n=57, obs=442) | P-INTf | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | ||
|
|
|
|
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| β1 (95% CI) | β2 | β3(95% CI) | β1 (95% CI) | β2 | β3(95% CI) | β1 (95% CI) | β2 | β3(95% CI) | ||
|
|
|
|
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| VRAM component | ||||||||||
| Time (seconds) | 4.6 (−5.0, 14.2) | ref | −2.1 (−11.7, 7.6) | 6.8 (−5.5, 19.3) | ref | 7.9 (−6.1, 21.8) | 2.7 (−13.3, 18.8) | ref | −9.2 (−24.8, 6.4) | 0.09 |
| Distance (maze units) | 1.2 (−0.4, 2.7) | ref | 0.5 (−1.0, 2.1) | 1.5 (−0.4, 3.4) | ref | 2.3 (0.1, 4.4)**g | 0.9 (−2.0, 3.7) | ref | −1.2 (−4.0, 1.5) | 0.05 |
| WMEh (count ratio) | 1.18 (0.96, 1.42) | ref | 1.08 (0.85, 1.30) | 1.27 (0.95, 1.70) | ref | 1.33 (1.01, 1.83)** | 1.07 (0.74, 1.49) | ref | 0.84 (0.57, 1.22) | 0.15 |
| RMEi (count ratio) | 1.06 (0.97, 1.16) | ref | 0.99 (0.92, 1.09) | 1.12 (1.00,1.24)* | ref | 1.10 (0.98, 1.24) | 0.93 (0.82, 1.06) | ref | 0.97 (0.82, 1.12) | 0.97 |
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| Postnatal Mnd | All subjects (n=137, obs=1056) | Girls (n=80, obs=614) | Boys (n=57, obs=442) | |||||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | ||
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|
|
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| β1 (95% CI) | β2 | β3 (95% CI) | β1 (95% CI) | β2 | β3 (95% CI) | β1 (95% CI) | β2 | β3 (95% CI) | ||
|
|
|
|
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| VRAM component | ||||||||||
| Time (seconds) | −6.5 (−16.1, 3.1) | ref | −6.6 (−16.1, 2.8) | −9.8 (−23.1, 3.4) | ref | −9.6 (−21.7, 2.4) | 2.0 (−12.9, 17.0) | ref | −1.8 (−18.5, 14.9) | 0.59 |
| Distance (maze units) | −0.6 (−2.1, 1.0) | ref | −0.6 (−2.1, 0.9) | −0.8 (−2.9, 1.4) | ref | −0.9 (−2.9, 1.0) | 0.02 (−2.6, 2.7) | ref | 0.3 (−2.7, 3.2) | 0.60 |
| WME (count ratio) | 0.95 (0.77, 1.17) | ref | 1.04 (0.82, 1.28) | 0.81 (0.59, 1.10) | ref | 0.99 (0.75, 1.30) | 1.24 (0.89, 1.68) | ref | 1.33 (0.89, 1.87) | 0.57 |
| RME (count ratio) | 0.91 (0.84, 1.02) | ref | 0.92 (0.83, 1.00) | 0.91 (0.80, 1.05) | ref | 0.89 (0.77, 1.01) | 0.97 (0.84, 1.17) | ref | 0.99 (0.88, 1.14) | 0.81 |
Models with all subjects included are adjusted for age, sex, socioeconomic status, videogame use, blood lead, trial, and tooth attrition.
Models stratified by sex are adjusted for age, socioeconomic status, videogame use, blood lead, trial, and tooth attrition.
Prenatal Mn tertile concentration ranges: T1: 0.11 – 0.36; T2: 0.36 – 0.50; T3: 0.50 – 0.89 (AUC 55Mn:43 Ca).
Postnatal Mn tertile concentration ranges: T1: 0.015 – 0.11; T2: 0.11 – 0.15; T3: 0.15 – 0.40 (AUC 55Mn:43 Ca).
Tertile 2 is referent.
P-INT is the p-value for the interaction term between sex and Mn tertile 3 (sex*Mn T3) in models with all subjects.
Significance levels are indicated as follows:
for p<0.10,
for p<0.05,
for p<0.01
Working memory errors
Reference memory errors