Table 1.

Results for the CEA and CA19-9 biomarkers.

CA19-9 related results
	Naive	Box-Cox	Kernel(BC)	GG	Kernel(GG)	Spline	Empirical using all data for CA19-9
FPR	TP̂R(95%CI)	TP̂R(95%CI)	TP̂R(95%CI)	TP̂R(95%CI)	TP̂R(95%CI)	TP̂R(95%CI)	TP̂R(95%CI)
0.01	0.091(0.052,0.219)	0.501(0.253,0.709)	0.515(0.255,0.686)	0.707(0.6406,0.8289)	0.710(0.614,0.781)	0.573(0.625,0.803)	0.384(0.291,0.674)
0.02	0.182(0.105,0.438)	0.554(0.339,0.741)	0.574(0.345,0.714)	0.711(0.6571,0.8327)	0.737(0.634,0.784)	0.617(0.641,0.806)	0.593(0.314,0.744)
0.04	0.364(0.209,0.756)	0.613(0.428,0.774)	0.637(0.456,0.746)	0.718(0.6776,0.8379)	0.767(0.656,0.789)	0.664(0.658,0.810)	0.686(0.500,0.802)
0.05	0.455(0.262,0.779)	0.633(0.463,0.785)	0.657(0.491,0.756)	0.722(0.6818,0.8401)	0.778(0.656,0.791)	0.680(0.664,0.811)	0.721(0.581,0.802)
0.10	0.756(0.524,0.837)	0.699(0.601,0.821)	0.712(0.594,0.790)	0.739(0.6981,0.8555)	0.813(0.676,0.796)	0.732(0.664,0.811)	0.756(0.651,0.826)
AUC:	0.795(0.773,0.898)	0.858(0.773,0.898)	0.846(0.773,0.898)	0.866(0.799,0.935)	0.906(0.729,0.832)	0.846(0.773,0.898)	0.865(0.816,0.917)
CEA related results
TPR	FP̂R(95%CI)	FP̂R(95%CI)	FP̂R(95%CI)	FP̂R(95%CI)	FP̂R(95%CI)	FP̂R(95%CI)
0.7	0.550(0.394,0.650)	0.417(0.235,0.591)	0.455(0.261,0.611)	-	-	0.364(0.193,0.993)	-
0.8	0.700(0.596,0.776)	0.561(0.358,0.720)	0.612(0.382,0.738)	-	-	0.473(0.236,0.999)	-
0.9	0.850(0.798,0.883)	0.748(0.535,0.857)	0.807(0.589,0.881)	-	-	0.618(0.306,1.000)	-
0.95	0.925(0.899,0.941)	0.863(0.686,0.928)	0.917(0.752,0.951)	-	-	0.723(0.356,1.000)	-
AUC:	0.656(0.577,0.735)	0.699(0.594,0.803)	0.686(0.584,0.786)	-	-	0.744(0.447,0.858)	-