Fig. 1.

Effects of mRK35 on body weight and skeletal muscle mass in C57BL/6 and C57Bl/10 mice. a Weekly body weights following weekly intraperitoneal (IP) administration of 10 mg/kg mRK35 or vehicle (PBS) in 8-week-old male C57Bl/6 mice. b Weekly whole body lean mass measured by NMR. c Tissue wet weights of the gastrocnemius bundle (Gastroc) and quadriceps (Quad) muscles harvested after 4 weeks of treatment. Both groups (mRK35 and vehicle) contained eight mice. d Tissue wet weights of the tibialis antirior (TA), gastrocnemius bundle, and quadriceps of 1-year old male C57Bl/10 mice following weekly IP administration of 10 mg/kg mRK35 or vehicle (PBS) for 4 weeks. Data plotted are means ± SEM. *p < 0.05 versus vehicle as measured by two tailed Student’s t test