Fig. 4.

Effect of domagrozumab on skeletal muscle in cynomolgus monkeys. a Percent change in leg lean muscle mass over vehicle (PBS), measured by DXA, following 8 weeks of treatment with 10 and 30 mg/kg domagrozumab. b Myostatin levels in serum collected from all monkeys. c Percent change from baseline (start of study) in axial muscle volume after 8 weeks of treatment. d Percent change from baseline in appendicular muscle volume after 8 weeks of treatment. N = 5 animals for vehicle and 10 mg/kg groups and 3 animals for 30 mg/kg group. Data plotted are means ± SEM. * denotes p < 0.05 via ANOVA with Fisher’s LSD post-test versus vehicle; # denotes p < 0.05 versus 10 mg/kg domagrozumab; denotes time of dosing