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IC50 values derived from the cell-based signaling assays
| Myostatin inhibitors | IC50 with ligand | |||||
|---|---|---|---|---|---|---|
| Myostatin | GDF-11 | Activin A | Activin B | Activin AB | BMP9 | |
| ActRIIB-Fc | < 1 nM | < 1 nM | < 1 nM | < 1 nM | < 1 nM | < 1 nM |
| Domagrozumab | < 1 nM | < 1 nM | > 1000 nM | 81 nM | > 1000 nM | > 1000 nM |
| mRK35 | < 1 nM | < 1 nM | > 1000 nM | 37 mM | > 1000 nM | > 1000 nM |
Representative IC50 values for a minimum of two assays. ActRIIB-FC activin receptor IIB-fragment crystallizable, GDF-11 growth differentiation factor-11
