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. 2017 Nov 6;214(11):3197–3206. doi: 10.1084/jem.20160301

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© 2017 Niwa-Kawakita et al.

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Figure 3. — Pml^−/− mice fail to activate p53 upon oxidative stress. (a) Graphs representing transcript levels for the indicated p53 target genes determined by transcriptomic arrays of Pml^−/− and Pml^+/+ mouse livers 2 and 6 h after APAP or vehicle injections. Mean values from two mice per condition are shown. Error bars represent SEM. (b) Table from the transcriptomic analysis in a indicating p53 targets and death regulators and the mRNA ratio in Pml^−/− versus Pml^+/+ mice. (c) Transcripts from WI-38 fibroblasts transduced with PML or control shRNA were quantified by quantitative PCR. Error bars represent SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001. (d) Western blot analysis of NRF2 protein from Pml^−/− and Pml^+/+ mouse livers (left; two representative untreated mice). Box and whisker plot (Tukey) showing NRF2 protein quantification from six mice (right; Mann–Whitney test: *, P < 0.05). (e) Levels of NRF2 target mRNAs (transcriptomic analysis in b) 2 h or 6 h after APAP treatment. Error bars represent SEM.