Figure 3.

Gag/Pol versus Nef/Env/Accessory-Regulatory protein-specific IFN-γ ELISPOT responses in VC compared with VNC children. (A) Breadth. (B) Magnitude. Magnitude of differences between five VC and six VNC children is as shown on each panel, in black text. Magnitude of differences between Gag/Pol and Nef/Env/Acc/Reg targeted responses is shown in red (VNC) or blue (VC) bold text. An estimate of best fit (LOWESS lines) is shown for each PSP group and antigen group in a thick solid line (Gag/Pol) or thick dotted line (Nef/Env/Acc/Reg). Corresponding 95% confidence intervals for best fit lines are denoted by the blue or red shaded areas. For each of the 11 individuals the sum of the breadth, or magnitude of responses to the combination of antigens (Gag/Pol or Nef/Env/Acc/Reg) was calculated at each time point, and p-values were determined by linear mixed-effects modeling that take into account all time points. SFC, spot-forming cell.