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. 2017 Nov 6;214(11):3239–3261. doi: 10.1084/jem.20162123

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© 2017 Leitman et al.

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Figure 4. — Escape in the immunodominant Gag-TL9 epitope develops in the first months of life in the VC child 133-C. (A) Virological profile of the child 133-C with deep-sequenced time points indicated by large circles and child’s age (years) indicated above the arrows. (B) ELISPOT CD8⁺ T cell responses in the VC child 133-C. (C) Contribution of different HIV proteins to HLA-associated escape across HIV proteome. VVVTR, Vif/Vpr/Vpu/Tat/Rev in 133-C. (D) Development of escape in Gag-TL9 epitope in the child 133-C. Q-values as per Carlson et al. (2012) and Carlson et al. (2014). (E) CD8⁺ T cell response to the Gag-TL9 wild-type epitope and its variants at five different time points in the child133-C. Responses were determined by IFN-γ ELISPOT assay. Assays repeated in triplicate. (F) Growth of viruses encoding TL9 wild-type and mutants T186M and T186S. Dotted line in the plot with viral growth curves indicates the threshold of 30% cells being infected at which time virus should be harvested. Each virus grown in triplicate; confirmed in two independent experiments. SFC, spot-forming cell.