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. 2017 Nov 6;214(11):3435–3448. doi: 10.1084/jem.20171129

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© 2017 Zaretsky et al.

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Figure 4. — B cell ICAMs are necessary for clonal competition but not for early B cell activation. (A) Flow cytometric plots and graphs showing the percentage of PE⁺ B cells among transferred IC-1/2^+/+ and IC-1/2^−/− B1-8^hi B cells 9 h after immunization with NP-PE. Data are pooled from two independent experiments with a total of 10 mice per group. (B) CD86 expression on follicular and PE⁺ IC-1/2^+/+ and IC-1/2^−/− B1-8^hi B cells. Data are pooled from two independent experiments with a total of eight to 10 mice per group. (C) Percentage of follicular and transferred PE⁺ B cells expressing low levels of IgD 16 h after immunization with NP-PE. Data are pooled from two independent experiments with a total of eight to 10 mice per group. Bars and error bars represent the mean and SEM, respectively. (D–F) Percentage of IC-1/2^+/+ and IC-1/2^−/− B1-8^hi B cells expressing FAS and GL-7 in host mice on the indicated days after NP-OVA (D, E) or NP-KLH (F) immunization. Data are pooled from two independent experiments with seven to 10 mice total for each condition or time point. Each dot in the graphs represents a single mouse; lines represent the mean. ***, P < 0.007; ns, not significant; two-tailed Student’s t test.