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. Author manuscript; available in PMC: 2018 Sep 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Aug 16;56(38):11404–11408. doi: 10.1002/anie.201704649

Figure 1.

Figure 1

Design and delivery mechanism of nano-peptisomes. Peptisomes are formed from an amphiphilic peptide containing a hydrophilic cell-binding sequence (orange) and a poly-cysteine cross-linking core (red). A C-terminal fluorinated amino acid block (dark green) promotes peptide assembly at the surface of the perfluorocarbon (PFC) liquid core (light green), containing the bioactive cargo (purple). Following binding of nano-peptisomes to the surface of cells, US-mediated vaporization of the fluorous liquid interior leads to a cavitation event that permeabilizes the cell membrane and delivers the loaded cargo into the cytoplasm.