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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2017 Mar 20;6(4):10.1002/wdev.270. doi: 10.1002/wdev.270

Figure 2. Factors that promote limb field initiation and initial AP polarity.

Figure 2

Initial forelimb AP polarity is related to the colinear expression of Hox genes along the rostrocaudal embryo axis (Hox5-9 paralogues). In contrast, initial hindlimb AP polarity is related to other factors expressed in the caudal region of the embryo such as Pitx1 and Islet1.