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. Author manuscript; available in PMC: 2018 Apr 17.
Published in final edited form as: Sci Signal. 2017 Oct 17;10(501):eaaj1784. doi: 10.1126/scisignal.aaj1784

Fig. 7. A signaling model for TSP1-induced senescence.

Fig. 7

Upon binding to CD47, TSP1 activates the Nox1 complex, which generates robust and sustained accumulation of ROS. In turn, this triggers committed senescence through a pathway involving p53-p21cip–induced DNA damage response and decreased Rb phosphorylation. This pathway can be disrupted using the selective Nox1 inhibitor NoxA1ds.