Table 3.
ECM-related Oligodendroglial Phenotypes
| Mouse | Protein modification |
Myelin phenotype | Remyelination | Oligodendrocyte Development |
Nodal Architecture |
References | ||
|---|---|---|---|---|---|---|---|---|
| Abnormal numbers of unmyelinated axons |
Thinner | Thicker | ||||||
| dy | Decreased expression of laminin α2 | Yes | Yes | No | N.D. | Delayed differentiation; reduced numbers of mature oligodendrocytes | N.D. | Chun 2003; Relucio 2009 |
| α6 integrin KO | Lack of α6 integrin | N.D. | N.D. | N.D. | N.D. | Reduced density of mature oligodendrocytes; increased oligodendrocyte apoptosis | N.D. | Colognato 2002 |
| Oligodendrocyte-specific β1 integrin KO (CNP-cre) | Lack of β1 integrin in oligodendrocytes | No | No | No | Normal | Decreased numbers of mature oligodendrocytes; increased mature oligodendrocyte apoptosis (cerebellum) | N.D. | Benninger 2006 |
| Oligodendrocyte-specific β1 integrin KO (NG2-cre) | Lack of β1 integrin in oligodendrocytes | No | Yes | No | N.D. | Normal | N.D. | Barros 2009 |
| Neural cell-specific β1 integrin KO (Nestin-Cre) | Lack of β1 integrin in oligodendrocytes, neurons and astrocytes | No | Yes | No | N.D. | N.D. | N.D. | Barros 2009 |
| Oligodendrocyte-specific dominant negative β1 integrin transgenic (PLP promoter) | Expression of a truncated β1 integrin transgene (lacking cytoplasmic domain) in oligodendrocytes | Yes | Yes | No | Normal | Decreased numbers of mature oligodendrocytes in spinal cord and optic nerve | N.D. | Lee 2006 |
| Oligodendrocyte-specific dominant negative β1 integrin transgenic (MBP promoter) | Expression of a mutant β1 integrin transgene (extracellular domain is replaced by extracellular domain of interleukin-2 receptor) in oligodendrocytes | Yes | No | No | N.D. | N.D. | N.D. | Camara 2009 |
| Oligodendrocyte-specific dominant negative β3 integrin transgenic (MBP promoter) | Expression of a mutant β3 integrin transgene (extracellular domain is replaced by extracellular domain of interleukin-2 receptor) in oligodendrocytes | No | No | No | N.D. | N.D. | N.D. | Camara 2009 |
| Oligodendrocyte-specific FAK KO (CNP-cre) | Lack of FAK in oligodendrocytes | Yes | No | No | N.D. | N.D. | N.D. | Camara 2009 |
| Oligodendrocyte-specific Cdc42 KO (CNP-cre) | Lack of Cdc42 in oligodendrocytes | No | Yes | No | N.D. | Normal oligodendrocyte differentiation; enlargement of the inner tongue of oligodendrocyte processes (outfoldings) | N.D. | Thurnherr 2006 |
| Oligodendrocyte-specific Rac1 KO (CNP-cre) | Lack of Rac1 in oligodendrocytes | No | N.D. | No | N.D. | Normal oligodendrocyte differentiation; enlargement of the inner tongue of oligodendrocyte processes (outfoldings) | N.D. | Thurnherr 2006 |
| Fyn KO/LOF | Lack of Fyn, or, lack of Fyn activity | Yes | Yes | No | N.D. | Impaired oligodendrocyte differentiation; decreased numbers of mature oligodendrocytes | N.D. | Umemori 1994, 1999; Sperber 2001; Osterhout et al 1999; Goto 2008 |