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. Author manuscript; available in PMC: 2018 Mar 20.
Published in final edited form as: Obesity (Silver Spring). 2017 Sep 20;25(11):1988–1996. doi: 10.1002/oby.21979

Table 3.

4-year weight change (lb) for every 1 drink per day change in alcohol intake among HPFS men without obesity2, 1986–2010 (n=14,971 men contributing 44,603 4-year periods)

Weight Change, lb
(95% CI)		 P-value Weight Change, lb
(95% CI)		 P-value Weight Change, lb
(95% CI)		 P-value P-
interaction
BMI at start of 4-year period
BMI <25 kg/m2 BMI 25 to <27.5 kg/m2 BMI 27.5 to <30 kg/m2
    # 4-year periods 21,961 15,733 6,909
Total Alcohol 0.21 (0.06, 0.36) 0.006 0.24 (0.04, 0.44) 0.02 0.31 (−0.04, 0.65) 0.08 0.47
Beer 0.27 (0.01, 0.52) 0.04 0.31 (−0.07, 0.68) 0.11 0.54 (−0.08, 1.17) 0.09 0.39
Wine 0.15 (−0.11, 0.40) 0.26 0.31 (−0.02, 0.63) 0.06 −0.03 (−0.69, 0.63) 0.93 0.82
Liquor 0.26 (0.00, 0.52) 0.05 0.26 (−0.06, 0.58) 0.11 0.35 (−0.21, 0.92) 0.22 0.63
Age at start of 4-year period
<55 years old 55 to <60 years old 60 to 65 years old
    # 4-year periods 22,360 10,651 11,592
Total Alcohol 0.37 (0.19, 0.54) <0.001 0.21 (−0.02, 0.43) 0.08 0.06 (−0.16, 0.27) 0.61 0.01
Beer 0.57 (0.28, 0.85) <0.001 0.14 (−0.30, 0.58) 0.53 −0.09 (−0.48, 0.30) 0.64 0.002
Wine 0.28 (−0.02, 0.57) 0.07 0.03 (−0.34, 0.40) 0.88 0.13 (−0.23, 0.49) 0.47 0.29
Liquor 0.32 (0.01, 0.64) 0.04 0.44 (0.06, 0.83) 0.02 0.10 (−0.24, 0.44) 0.56 0.27
Total alcohol intake (drinks/day) at start of 4-year period
≤1 drinks/day >1 to 2 drinks/day >2 to 4 drinks/day
    # 4-year periods 29,329 8,749 5,360
Total Alcohol 0.43 (0.18, 0.68) 0.001 0.29 (0.07, 0.51) 0.01 0.29 (0.09, 0.49) 0.005 0.04
Beer 0.78 (0.34, 1.23) 0.001 0.32 (−0.10, 0.73) 0.14 0.24 (−0.08, 0.56) 0.15 0.06
Wine 0.12 (−0.30, 0.54) 0.57 0.18 (−0.16, 0.52) 0.31 0.22 (−0.12, 0.56) 0.20 0.90
Liquor 0.60 (0.14, 1.06) 0.01 0.38 (0.01, 0.76) 0.04 0.47 (0.16, 0.78) 0.003 0.04
1

Multivariable-adjusted models are adjusted for age (years) at start of each 4-year period, year (at start of 4-year period), history of high cholesterol (ever, never), history of high blood pressure (ever, never), 4-year change in the following time-varying covariates: smoking status (current, past, never), total physical activity (MET hours per week), vigorous physical activity (MET hours per week), watching TV (hours per week), sleep (hours per night), and 4-year change in the following dietary covariates (servings/day): fried potatoes, fruits, vegetables, juice, whole grains, refined grains, fried foods, processed meat, non-processed meat, nuts, coffee, sweets, sugar sweetened beverages (other than juice), diet beverages, whole-fat dairy products, low-fat dairy products, seafood, and trans fat. Beer, wine, and liquor were also mutually adjusted for each other. When total alcohol intake was the main exposure models were not adjusted for any alcohol subtypes. Models were not adjusted for the stratification variable.

2

Men with obesity are not included in any other part of this analysis