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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: J Immunol. 2017 Sep 20;199(8):2823–2833. doi: 10.4049/jimmunol.1500832

Figure 3. NLRP10−/− mice on a BALB/cJ background have increased lesion size and increased parasites in the visceral organs.

Figure 3

Mice were inoculated with 5×105 luciferase expressing L. major metacyclic promastigotes intradermally in the ear pinna. Panels show (A) Lesion size according to ear thickness measured by calipers, (B) parasite burden according to light generated from luciferase-expressing parasites in the presence of luciferin, and (C) ulceration according to visual inspection, observed for 8 weeks after parasite inoculation. (D-G) Parasite burdens were measured by qPCR in the indicated tissues after euthanizing groups of mice infected for 8 weeks. Results show the mean ± SEM of three independent experiments, each with 3–5 mice per group. Statistical analyses were done by one- or 2-way analysis of variance.