Figure 9. NLRP10 is required in the non-hematopoietic compartment for control of inflammation and ulceration.

Bone marrow chimeras (donor hematopoietic cells->irradiated recipient; WT, wild type; 10, NLRP10^−/−) were inoculated with 5×10⁵ L. major luciferase expressing stationary promastigotes intradermally in the ear pinna. (A) Lesion thickness and (B) ulceration were monitored by weekly caliper measurements of ear thickness and by visual inspection, respectively, for 10 weeks. Data show results in groups of 10 mice. Symbols indicate statistical comparisons between the groups that reached significance at the p<0.05 level (two way ANOVA). Groups with significant differences were: *WT→WT versus NLRP10^−/−→ NLRP10^−/−; +WT→WT versus WT→ NLRP10^−/−; ^ NLRP10^−/−→WT versus NLRP10^−/−→ NLRP10^−/−; # NLRP10^−/−→WT versus WT→NLRP10^−/−