REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Histone H3K9me3	Abcam	Cat# ab8898; RRID: AB_306848
Anti-Histone H3K20me3	Abcam	Cat# ab9052; RRID: AB_1951942
Anti-Insulin	Abcam	Cat# ab7842; RRID: AB_306130
Anti-Cytokeratin 15 [EPR1614Y]	Abcam	Cat# ab52816; RRID: AB_869863
Anti-cMyc	Abcam	Cat# ab32072; RRID:AB_731658
Anti-Integrin a 6 (ITGA6) [EPR5578]	Abcam	Cat# ab124924; RRID: AB_11127843
Anti-Oct-3/4 (C-10)	Santa Cruz Biotechnology	Cat# sc-5279; RRID: AB_628051
Anti-Lamin A/C (346)	Santa Cruz Biotechnology	Cat# sc-7293; RRID: AB_627874
Anti-Sox2	Cell Signaling Technology	Cat# 2748; RRID: AB_823640
Anti-Sox2 (C70B1)	Cell Signaling Technology	Cat# 3728; RRID: AB_2194037
Anti-Ki67 (D2H10)	Cell Signaling Technology	Cat# 9027
Anti-phospho-Histone H2A.X (Ser139) (20E3)	Cell Signaling Technology	Cat# 9718; RRID: AB_2118009
Anti-Laminin	Sigma	Cat# L9393; RRID: AB_477163
Anti-53BP1	Novus Biologicals	Cat# NB100-904; RRID: AB_10002714
Anti-Nanog	Novus Biologicals	Cat# NB100-58842; RRID: AB_877697
Anti-Pax7	DSHB	Cat# Pax7; RRID: AB_528428
Anti-b-galactosidase	EMD Millipore	Cat# AB986; RRID: AB_92401
Chemicals, Peptides, and Recombinant Proteins
Doxycycline	Sigma	Cat# D9891
Streptozocin (STZ)	Sigma	Cat# S0130
Cardiotoxin (CTX)	Latoxan	Cat# L8102
Fluoromount-G	SouthernBiotech	Cat# 0100-01
HistoVT One (10x, pH 7.0)	Nacalai Tesque	Cat# 06380-05
Polybrene	Millipore	Cat# TR-1003
BLOXALL	Vector Laboratories	Cat# SP-6000
ImmPRESS HRP anti-Mouse IgG (Peroxidase) detection kit	Vector Laboratories	Cat# MP-7402
ImmPRESS HRP anti-Rabbit IgG (Peroxidase) detection kit	Vector Laboratories	Cat# MP-7401
ImmPACT DAB Peroxidase (HRP) substrate	Vector Laboratories	Cat# SK-4105
Quick Start Bradford protein assay	Bio-Rad	Cat# 5000201
NuPAGE Novex 4%–12% Bis-Tris protein gels	ThermoFisher Scientific	Cat# NP0321
Immobilon-P Membrane, PVDF	Millipore	Cat# IPVH00010
ECL SuperSignal	GE Healthcare	Cat# RPN2232
Chaetocin	Sigma	Cat# C9492
OneTouch Ultra2 Meter	OneTouch	Cat# 021098
OneTouch Ultra Blue Strips	OneTouch	Cat# 020994
Formalin solution	Sigma	Cat# HT501128
DMEM GlutaMAX	ThermoFisher Scientific	Cat# 10566024
Non-essential amino acids (NEAA)	ThermoFisher Scientific	Cat# 11140050
FBS	Gemini Bio-products	Cat# 100-106
Lipofectamine 3000	ThermoFisher Scientific	Cat# L3000-015
MitoSox Red	Molecular Probes	Cat# M36008
iScript Reverse Transcription Supermix	Bio-Rad	Cat# 1708840
SsoAdvanced SYBR Green Supermix	Bio-Rad	Cat# 1725270
Hoechst 33342	ThermoFisher Scientific	Cat# 62249
TRIzol	ThermoFisher Scientific	Cat# 15596026
X-Gal	Apex	Cat# 20-108
Critical Commercial Assays
Alexa Fluor 488 Annexin V/Dead Cell Apoptosis kit	ThermoFisher Scientific	Cat# V13241
Experimental Models: Cell Lines
Primary Tail Tip Fibroblasts (TTFs) WT	This paper	N/A
Primary Tail Tip Fibroblasts (TTFs) WT 4F	This paper	N/A
Primary Tail Tip Fibroblasts (TTFs) LAKI 4F	This paper	N/A
Human 4F iPSCs	Jaenisch lab	N/A
Experimental Models: Organisms/Strains
LAKI mice (LMNA mutation G609G)	Brian Kennedy, Buck Institute	N/A
R26rtTA;Col1a12lox–4F2A	The Jackson Laboratory	JAX: 011011
C57BL/6J mice	The Jackson Laboratory	JAX: 000664
Recombinant DNA
pMXs-Oct3/4	Addgene	Cat#13366
pMXs-Sox2	Addgene	Cat#13367
pMXs-Klf4	Addgene	Cat#13370
pMXs-c-Myc	Addgene	Cat#13375
Gag/pol	Addgene	Cat#14887
pCMV-VSV-G	Addgene	Cat#8454
pMXs-GFP	This paper	N/A
Sequence-Based Reagents
See Table S1 for qPCR primer list	N/A	N/A
Software and Algorithms
Prism 6	GraphPad Software	http://www.graphpad.com
ImageJ	NIH	https://imagej.nih.gov/ij/
Imaris 8.0	Bitplane	http://www.bitplane.com
LabChart	AD Instruments	https://www.adinstruments.com/products/labchart