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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Endocrinol Metab. 2017 Sep 7;28(10):722–734. doi: 10.1016/j.tem.2017.07.004

Table I.

Alterations of shelterin proteins and telomere binding proteins in long-lived species

Genes Alterations Species Control species Refs
Tep1, Terf1 Positive selection Naked mole rat Multiple other mammals [129]
Rif1, Terf1, Tinf2 Upregulation Long-lived bats and rodents Short-lived counterparts [61]
Tinf2 Expansion Naked mole rat Mouse, rat, human, and chimpanzee [65]