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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: Chem Mater. 2017 Sep 15;29(20):8766–8779. doi: 10.1021/acs.chemmater.7b03033

Figure 7.

Figure 7

Biodistribution studies in M21 tumor-bearing mice using cRGDY–PEG–Cy5–C′ dots of varying ligand number. Biodistribution patterns and tumor-to-background ratios observed in M21-xenografted mice following i.v.-injection of 131I–cRGDY–PEG–Cy5–C′ dots over a range of p.i. time points (i.e., 1–96 h) (n = 3): (A, and B) 6 cRGDY/C′ dot, (C and D) 14 cRGDY/C′ dot, and (E and F) 18 cRGDY/C′ dot. Insets in A, C, and E show corresponding urine uptake (presented as %ID/g) and retained activity in mice carcasses (presented as %ID) at different p.i. time points.