Scheme 1.

Illustration of C′ Dot Production and Molecular Rendering of ¹²⁴I-Labeled cRGDY–PEG–Cy5–C′ Dots^a

^a(A) Production process of radiolabeled C′ dots for clinical use, including particle synthesis, product purification, and radio-labeling steps. C′ dots are ready for clinical use as optical probes after the purification step. A subsequent radio-labeling step enables use of additional imaging modalities (e.g., PET). (B) Molecular rendering of ¹²⁴I-labeled cRGDY–PEG–Cy5–C′ dots. The atoms of silicon, oxygen, carbon, nitrogen, sulfur, hydrogen, and iodine are colored in purple, red, gray, blue, yellow, white, and green, respectively. Hydrogen atoms are not displayed in the stick model (left) for better visualization but are displayed in the sphere model (right).