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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2017 Oct;10(5):e001736. doi: 10.1161/CIRCGENETICS.117.001736

Table 2.

Risk of mitral regurgitation according to parental or sibling mitral regurgitation in the Framingham Heart Study.

Mitral Regurgitation
OR 95% CI P value
Parental mitral regurgitation
Model 1: sex + age 1.34 1.00 1.79 0.04
Model 2: model 1 + risk factors* 1.31 0.98 1.74 0.07
Model 3: model 2 excluding MVP 1.25 0.93 1.67 0.14
Model 4: model 2 + ≥ moderate MR only 1.42 0.97 2.06 0.07
Model 5: model 3 + ≥ moderate MR only 1.35 0.92 1.99 0.13
Sibling mitral regurgitation
Model 1: sex + age 1.25 1.06 1.48 0.01
Model 2: model 1 + risk factors* 1.20 1.01 1.43 0.04
Model 3: model 2 excluding MVP 1.23 1.02 1.48 0.03
Model 4: model 2 + ≥ moderate MR only 1.78 1.25 2.53 0.002
Model 5: model 3 + ≥ moderate MR only 1.67 1.10 2.54 0.02

OR = odds ratio; CI = confidence interval; risk factors* = body mass index, systolic/diastolic blood pressure, diabetes, chronic obstructive pulmonary disease, history of myocardial infarction; MVP = mitral valve prolapse.