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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Immunol. 2017 Oct 2;199(9):3187–3201. doi: 10.4049/jimmunol.1700851

FIGURE 6.

FIGURE 6

Inflated DYS+ CD4+ T cells have a CD127− TIGIT− Granzyme B+ phenotype. Ex vivo comparisons of (A) CD127, (B) PD-1, (C) TIGIT, (D) Granzyme B expressions or (E) Bcl-2 median fluorescence intensity (MFI) of DYS+ CD4+ TEM of HIV+ HCMV+ subjects to DYS− CD4+ TEM of HIV− HCMV− controls. PBMCs were stained with tetramer and mAbs for either surface PD-1, CD127 and TIGIT or intracellular granzyme B and Bcl-2 proteins. HIV+ HCMV+: n=7, HIV− HCMV+: n=10 and HIV− HCMV−: n=10. Graphs represent single experiments for each subject, with mean±95% CI for all subjects.