Fig. 3.

The impact of genetically deleting endothelial β4 integrin on clinical severity in EAE. The progression of EAE in the β4-EC-KO and WT littermate control mice was evaluated by measuring clinical score on daily intervals. All points represent the mean ± SD (n = 16 mice per strain). Note that while the β4-EC-KO mice showed the same time of disease onset as the WT littermates, over time, they developed significantly worse clinical disease, resulting in increased mean clinical score for the duration of the experiment. This result was confirmed in three separate experiments. *p < 0.05, **p < 0.01