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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Trends Pharmacol Sci. 2017 Feb 14;38(4):339–362. doi: 10.1016/j.tips.2017.01.004

Figure 4. Proposed mechanisms for toxtazins A and B inhibition of cholera toxin and toxin co-regulated pilus production.

Figure 4

ToxT regulates transcription of genes responsible for producing cholera toxin (CT) and the toxin co-regulated pilus (TCP), which are two virulence factors involved in cholera infections. Toxtazin A inhibits toxT transcription and is proposed to act by causing a general stress response, feeding back to shut down transcription of toxT. Toxtazin B inhibits transcription of tcpPH and is proposed to act by reducing intracellular levels of TcpP, leading to reduced transcription of toxT. Inhibitors are in red. OM – bacterial outermembrane; IM – bacterial inner membrane. This model is derived and modified from Anthouard et al. [26]