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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2017 Oct;10(5):e001770. doi: 10.1161/CIRCGENETICS.117.001770

Figure 4. Specific pathways and functions are enriched in cardiac myocytes from either sex.

Figure 4

IPA analysis of significantly expressed genes by at least 1.5 fold in either sex. (A) The top ten statistically significant canonical pathways predicted to be activated by IPA in genes unregulated in either male or female cardac myocytes. Pathways were deemed statistically significant by IPA if p<0.05 using the Fischer exact test. Activated pathways were indicated by positive z-scores calculated by IPA; for pathways that contained the same genes, the pathway with the lower p-value was listed. (B) The top five statistically significant (lower end of p-value overlap at least 0.05) molecular and cellular functions enriched in genes found to be upregulated in either male or female myocytes by IPA. (C) The number of statistically significant (p<0.05) upstream regulators enriched in up-regulated genes from either sex as measured by IPA analysis.