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. Author manuscript; available in PMC: 2018 Nov 2.
Published in final edited form as: Cell. 2017 Sep 28;171(4):877–889.e17. doi: 10.1016/j.cell.2017.09.003

Figure 7. Conserved and unique features of m6A mRNA methylation in human forebrain organoids, human fetal brain and embryonic mouse forebrain.

Figure 7

(A) Representative plots of two m6A-tagged transcripts in day 47 human forebrain organoids and PCW11 human fetal brain, but not in mouse E13.5 forebrain.

(B) Venn diagram showing shared m6A-tagged transcripts between day 47 human forebrain organoids and PCW11 fetal human brain.

(C) GO and disease ontology analyses of shared m6A-tagged genes in day 47 human forebrain organoids and PCW11 human fetal brain.

(D) Venn diagram showing shared and unique m6A-tagged transcripts among mouse E13.5 forebrain, day 47 human forebrain cortex, and PCW11 fetal human brain. Only ortholog genes expressed in all three samples were used for analysis.

(E–F) Disease ontology analysis of transcripts uniquely m6A-tagged in human shows enrichment for neurodevelopmental diseases, whereas disease ontology analysis of commonly m6A-tagged transcripts showed enrichment for oncogenic processes.

See also Figure S7, and Table S2 and S5.