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. 2017 Nov 9;17:736. doi: 10.1186/s12885-017-3714-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Melanomas from trigenic RXRα ^ep−/−|TyrNRAS ^Q61K|Cdk4 ^R24C/R24C mice display reduced apoptosis relative to their controls with functional RXRα. a, b TUNEL assay to label apoptotic cells. Apoptotic cells are indicated by green staining (top panel), blue color corresponds to DAPI staining of the nuclei (middle panel) and merged TUNEL and DAPI cells (lower panel). Overall, reduced TUNEL positive staining was observed in lesions from trigenic Rxrα^ep−/− mice compared to their respective controls in mice with (a) no UVB treatment as well as the (b) acute UVB treated mice. c, d Bar-graph represents TUNEL+ melanocytes/ field in no UVB and acute UVB treatment respectively