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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Circ Heart Fail. 2017 Oct;10(10):e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140

Figure 1. Dysregulation of autophagy in HCM patients with MYBPC3 mutations.

Figure 1

Myectomy samples of HCM patients or heart samples from non-failing (NF) individuals were analyzed. A, Representative Western blots of p62, beclin-1 and LC3. Ponceau was used as loading control. Quantification of B, p62, C, beclin-1, D, LC3-I and E, LC3-II. Data are expressed as mean + s.e.m with *P<0.05 vs. NF, unpaired Student’s t-test. Number of individuals is indicated in the bars. F, Heatmap of selected genes comparing gene expression of proteins modulating hypertrophy, fibrosis, calcium handling, autophagy and potassium handling in NF and HCM (threshold <0.8- or >1.2-fold change to NF).