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ADAM17 antibody attenuated AAA development. C57Bl6 mice were received AngII plus BAPN together with ADAM17 antibody A9B8 or control IgG2 as in Figure 3. A. Measurements of maximal external width of abdominal aorta upon fixation at 4 weeks (n=6). B. Weekly ultrasound evaluation of maximal abdominal aorta luminal diameter. *, † p<0.05 compared with control saline or AngII/BAPN infusion, respectively (each n=6~7).
