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Time evolution of TIRFM signals from a 10ms single Ca2+-channel opening with increasing value of [EGTA]. For all simulations DCa=223µm2/s, DCaF=74µm2/s, αf=100/(µMs), and βf=33/s was used. The top and bottom-inset shows the peak ΔF/Fo and time to equilibrate after the channel closes as a function of mobile buffer, respectively.
