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. Author manuscript; available in PMC: 2018 Nov 7.
Published in final edited form as: Cell Metab. 2017 Oct 5;26(5):709–718.e3. doi: 10.1016/j.cmet.2017.09.005

Figure 3. β-Klotho in adipose tissue is required for the acute insulin-sensitizing actions of FGF21 and FGF19.

Figure 3

(A) DIO Klbfl/fl and KlbAdipoq littermates were treated with FGF21 or vehicle during a hyperinsulinemic-euglycemic clamp and glucose infusion rate, endogenous glucose production and whole-body glucose uptake during the clamp and basal endogenous glucose production measured. n = 5–6/group.

(B) DIO Klbfl/fl and KlbAdipoq littermates were treated with FGF19 or vehicle during a hyperinsulinemic-euglycemic clamp and glucose infusion rate, endogenous glucose production and whole-body glucose uptake during the clamp and basal endogenous glucose production measured. n = 6–8/group.

Data are shown as the mean ± SEM. *p < 0.05, **p < 0.01 compared to control. Significant interactions between genotype (Klbfl/fl vs. KlbAdipoq) and treatment (Vehicle vs. FGF21) were detected for glucose infusion rate (p=0.03) and endogenous glucose production (p=0.02).

See also Table S1.