Figure 5.

Classical monocytes do not mediate neutrophil infiltration into the brain after TBI: (A–E) intravenous administration of two doses, 25ug each, of anti-CCR2 mAb completely eradicate the circulating classical monocytes P ≤ 0.002, but leaves the non-classical monocyte population unaffected. (F–G) Depletion of classical monocytes does not inhibit neutrophil infiltration into the brain. (H) Depletion of classical monocytes inhibit monocyte derived macrophage recruitment after TBI P ≤ 0.004. All tests are non-paired non parametric Mann-Whitney tests and mice n=15